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KMID : 0377520160410020025
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Chung-Ang Journal of Medicine
2016 Volume.41 No. 2 p.25 ~ p.33
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Clinical Analysis of Newborn Rotavirus Infection for 9 Years in a Single Center
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Ahn Sung-Yoon
Kang Kook-Jin
Choi Yu-Mi
Ko Jeong-Hee
Choi Kyung-Eun
Lee Won-Uk
Kim Eun-Ryoung
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Abstract
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Objective: Rotavirus infection is the most common cause of acute diarrhea in children worldwide and is usually asymptomatic in neonates. However, it might cause necrotizing enterocolitis or even neonatal death in some cases. We investigated the infection rate and clinical manifestations of rotavirus infection in newborn admitted in neonatal intensive care unit (NICU).
Methods: We retrospectively analyzed the medical records of 260 neonates admitted to the Sung-Ae General Hospital NICU from June 2005 to May 2014, who were diagnosed with rotavirus infection within 48 hours after admission. We defined the diagnosis of rotavirus infection as the positive result of a rotavirus stool antigen test. We defined the symptomatic group as the patients who showed at least one symptom of fever, vomiting, diarrhea, weight loss, metabolic acidosis and/or poor oral intake.
Results: The rotavirus infection rate was from 7% to 27% annually. The symptomatic group consisted 60% of total infected patients and symptoms included weight loss (28.3%), fever (25.8%), diarrhea (20.5%), vomiting (18.5%), poor oral intake (8.1%) and metabolic acidosis (6.0%). There were more patients with history of normal spontaneous vaginal delivery (NSVD) in the asymptomatic group than in symptomatic group (83.7% vs 64.7%, p =0.001), and mean age of asymptomatic group was smaller than that of the symptomatic group (7.3±4.0 days vs 8.7±5.2 days, p =0.017). Birth-weight of the asymptomatic group was smaller than that of the symptomatic group (3.2±0.4 kg vs 3.4±0.4 kg, p =0.012).
Conclusion: Rotavirus infection rate of the patients admitted to the NICU shows increasing tendency annually, irrespectively with rotavirus vaccination, and about one third of rotavirus infected neonates are asymptomatic. All neonates admitted to the NICU can be possible infection sources, so we should continually monitor the rotavirus infection.
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KEYWORD
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Rotavirus infection, Newborn, Asymptomatic
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